The science of microbes started when people learnt to grind glass and make lenses of different thickness out of them. We developed the curiosity to see through them. This gave us the amazing power to see beyond the limits of our vision. It was then we realized that our world was inhabited with a near infinite number and varieties of microorganisms. They were found everywhere, in rain water poodles and tooth scum, in vinegar and alcohols. Microorganisms were revealed from a variety of specimens. Initially these observations were a great source of curiosity. During the period from 1600 to 1800, considerable information accumulated about the occurrence of these microscopic forms of life. Great debates emerged as the origin of these microbes.